FOB Price
Get Latest Price( Negotiable )
|20 Milligram Minimum Order
Country:
China
Model No:
CPE10009
FOB Price:
( Negotiable )Get Latest Price
Place of Origin:
nanjing,china
Price for Minimum Order:
-
Minimum Order Quantity:
20 Milligram
Packaging Detail:
25kg/drum or according to customer's requirement
Delivery Time:
Immediate export after the contract confirmed
Supplying Ability:
100 Kilogram per Week
Payment Type:
Western Union, L/C, T/T
Product Group :
Contact Person Mr. salem
qixia, Nanjing, Jiangsu
CAS No: ******8
EINECS No: ********5
Molecular formula: C*2H*5NO6
Molecular weight: **9.**7
|
Colchicine is an ancient remedy for
the treatment of articular pain. Use of Colchicum alkaloid for the
treatment of acute gout occurred as early as ***0, and reports of
its medicinal value exist from the first century AD. Colchicine is
the preferred agent in the treatment of acute gouty arthritis.
Colchicine treats joint pain and swelling due to gout. Colchicine
also helps to prevent gout and gouty attacks. Colchicine relieves
pain and reduces the inflammation of acute gouty arthritis. Generic
colchicine tablets are available.
Description and Function:
Colchicine is a toxic natural product and secondary metabolite,
originally extracted from plants of the genus Colchicum (Autumn
crocus, Colchicum autumnale, also known as the "Meadow saffron").
Originally used to treat rheumatic complaints and especially gout,
it was also prescribed for its cathartic and emetic effects. Its
present medicinal use is mainly in the treatment of gout; as well,
it is being investigated for its potential use as an anti-cancer
drug. It can also be used as initial treatment for pericarditis and
preventing recurrences of the condition. In neurons, axoplasmic
transport is disrupted by colchicine.
Colchicine inhibits microtubule polymerization by binding to
tubulin, one of the main constituents of microtubules. Availability
of tubulin is essential to mitosis, and therefore colchicine
effectively functions as a mitotic poison or spindle poison. Since
one of the defining characteristics of cancer cells is a
significantly increased rate of mitosis, this means that cancer
cells are significantly more vulnerable to colchicine poisoning
than are normal cells. However, the therapeutic value of colchicine
against cancer is (as is typical with chemotherapy agents) limited
by its toxicity against normal cells.
Apart from inhibiting mitosis, a process heavily dependent on
cytoskeletal changes, colchicine also inhibits neutrophil motility
and activity, leading to a net anti-inflammatory effect. Colchicine
also inhibits uric acid (urate) crystal deposition, which is
enhanced by a low pH in the tissues, probably by inhibiting
oxidation of glucose and subsequent lactic acid production in
leukocytes. The inhibition of uric acid crystals is a vital aspect
on the mechanism of gout treatment.
If you have any questions ,please don't hesitate to contact with me.
Country: | China |
Model No: | CPE10009 |
FOB Price: | ( Negotiable ) Get Latest Price |
Place of Origin: | nanjing,china |
Price for Minimum Order: | - |
Minimum Order Quantity: | 20 Milligram |
Packaging Detail: | 25kg/drum or according to customer's requirement |
Delivery Time: | Immediate export after the contract confirmed |
Supplying Ability: | 100 Kilogram per Week |
Payment Type: | Western Union, L/C, T/T |
Product Group : | plant extract |